Perhaps that was a more cheerful time for observers and theorizers than
the present; we are apt to think it the finest era of the world when
America was beginning to be discovered, when a bold sailor, even if he
were wrecked, might alight on a new kingdom; and about 1829 the dark
territories of Pathology were a fine America for a spirited young
adventurer. Lydgate was ambitious above all to contribute towards
enlarging the scientific, rational basis of his profession. The more
he became interested in special questions of disease, such as the
nature of fever or fevers, the more keenly he felt the need for that
fundamental knowledge of structure which just at the beginning of the
century had been illuminated by the brief and glorious career of
Bichat, who died when he was only one-and-thirty, but, like another
Alexander, left a realm large enough for many heirs. That great
Frenchman first carried out the conception that living bodies,
fundamentally considered, are not associations of organs which can be
understood by studying them first apart, and then as it were federally;
but must be regarded as consisting of certain primary webs or tissues,
out of which the various organs--brain, heart, lungs, and so on--are
compacted, as the various accommodations of a house are built up in
various proportions of wood, iron, stone, brick, zinc, and the rest,
each material having its peculiar composition and proportions. No man,
one sees, can understand and estimate the entire structure or its
parts--what are its frailties and what its repairs, without knowing the
nature of the materials. And the conception wrought out by Bichat,
with his detailed study of the different tissues, acted necessarily on
medical questions as the turning of gas-light would act on a dim,
oil-lit street, showing new connections and hitherto hidden facts of
structure which must be taken into account in considering the symptoms
of maladies and the action of medicaments. But results which depend on
human conscience and intelligence work slowly, and now at the end of
1829, most medical practice was still strutting or shambling along the
old paths, and there was still scientific work to be done which might
have seemed to be a direct sequence of Bichat's. This great seer did
not go beyond the consideration of the tissues as ultimate facts in the
living organism, marking the limit of anatomical analysis; but it was
open to another mind to say, have not these structures some common
basis from which they have all started, as your sarsnet, gauze, net,
satin, and velvet from the raw cocoon? Here would be another light, as
of oxy-hydrogen, showing the very grain of things, and revising all
former explanations. Of this sequence to Bichat's work, already
vibrating along many currents of the European mind, Lydgate was
enamoured; he longed to demonstrate the more intimate relations of
living structure, and help to define men's thought more accurately
after the true order. The work had not yet been done, but only
prepared for those who knew how to use the preparation. What was the
primitive tissue? In that way Lydgate put the question--not quite in
the way required by the awaiting answer; but such missing of the right
word befalls many seekers. And he counted on quiet intervals to be
watchfully seized, for taking up the threads of investigation--on many
hints to be won from diligent application, not only of the scalpel, but
of the microscope, which research had begun to use again with new
enthusiasm of reliance. Such was Lydgate's plan of his future: to do
good small work for Middlemarch, and great work for the world.